Journal article
Environmental and demographic risk factors for egg allergy in a population-based study of infants
JJ Koplin, SC Dharmage, AL Ponsonby, MLK Tang, AJ Lowe, LC Gurrin, NJ Osborne, PE Martin, MN Robinson, M Wake, DJ Hill, KJ Allen
Allergy European Journal of Allergy and Clinical Immunology | WILEY | Published : 2012
DOI: 10.1111/all.12015
Abstract
Background Although egg allergy is the most common food allergy in infants and young children, risk factors for egg allergy remain largely unknown. This study examined the relationship between environmental and demographic factors and egg allergy in a population-based infant cohort. Methods In a study of 5276 infants (HealthNuts), infants underwent skin prick testing (SPT) to egg white at 12 months of age. Questionnaire data on relevant exposures were obtained. 699/873 (80%) infants eligible for oral food challenge (detectable wheal on SPT) attended for formal assessment of egg allergy status; 453 had confirmed egg allergy (positive challenge and SPT ≥ 2 mm). Associations between environment..
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Funding Acknowledgements
This work was supported by funding from the National Health & Medical Research Council (NHMRC) of Australia, Ilhan Food Allergy Foundation, AnaphylaxiStop, the Charles and Sylvia Viertel Medical Research Foundation and the Victorian Government's Operational Infrastructure Support Program. KJA is a Viertel senior medical research fellow. JK is supported by a postdoctoral fellowship from an NHMRC Capacity Building Grant in Population Health. PEM is an Australian Postgraduate Award scholar. LG, MW, MM, AL, A-LP and SD hold NHMRC awards.The European Centre for the Environment and Human Health (part of the Peninsula College of Medicine and Dentistry which is a joint entity of the University of Exeter, the University of Plymouth and the NHS in the South West) is supported by investment from the European Regional Development Fund and the European Social Fund Convergence Programme for Cornwall and the Isles of Scilly.